자가면역질환 모델 시스템 확립 연구
질환 특이적인 역분화 줄기세포 생성
환자의 역분화 줄기세포를 이용한 다양한 질환 modeling 기술 개발
역분화 줄기세포를 이용한 drug screening system 구축
세포치료제 기반 바이오 의약품 개발 연구
구조 기반 유전체 통합 조절 시스템 구축
학력
2007-2011 성균관대학교 약학대학 약학과 약학박사 (Biochemistry and Molecular Biology)
2005-2007 성균관대학교 약학대학 약학과 약학석사 (Biochemistry and Molecular Biology)
2001-2005 성균관대학교 약학대학 약학과 약학사
약력/경력
2011-2012 성균관대학교 에피지놈제어연구센터 선임연구원
2012-2017 Stanford University, School of Medicine, Post-¬doctoral Researcher
2017-2018 Stanford University, School of Medicine, 연구교수
(2023)
Gas slow conformational transition upon GTP binding and a novel Gas regulator.
ISCIENCE.
26,
5
(2023)
Application of RapidHIT™ ID for cell authentication by fast and convenient STR profiling.
GENES & GENOMICS.
45,
10
(2022)
Effect of Secondary Structures on the Adsorption of Peptides onto Hydrophobic Solid Surfaces Revealed by SALDI-TOF and MD Simulations.
ACS OMEGA.
7,
48
(2022)
S6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2.
EXPERIMENTAL AND MOLECULAR MEDICINE.
54,
3
(2022)
Nuclear S6K1 regulates cAMP-responsive element-dependent gene transcription through activation of mTOR signal pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
594,
-
(2021)
Transcriptomics-Based Repositioning of Natural Compound, Eudesmin, as a PRC2 Modulator.
MOLECULES.
26,
18
(2021)
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.
SCIENTIFIC REPORTS.
11,
1
(2021)
Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness.
CELL CHEMICAL BIOLOGY.
28,
5
(2021)
Anti-Adipogenic Polyacetylene Glycosides from the Florets of Safflower (Carthamus tinctorius).
BIOMEDICINES.
9,
1
(2020)
Rosmarinic Acid Methyl Ester Regulates Ovarian Cancer Cell Migration and Reverses Cisplatin Resistance by Inhibiting the Expression of Forkhead Box M1.
PHARMACEUTICALS.
13,
10
(2020)
Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus.
VIRUSES-BASEL.
12,
9
(2020)
In vitro modeling for inherited neurological diseases using induced pluripotent stem cells: from 2D to organoid.
ARCHIVES OF PHARMACAL RESEARCH.
43,
9
(2020)
Discovery of Dihydrophaseic Acid Glucosides from the Florets of Carthamus tinctorius.
PLANTS-BASEL.
9,
7
(2020)
HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53.
CELL DEATH AND DIFFERENTIATION.
27,
9
(2020)
Ginsenoside Rg3 Induces Browning of 3T3-L1 Adipocytes by Activating AMPK Signaling.
NUTRIENTS.
12,
2
(2020)
(+/-)-Kituramides A and B, pairs of enantiomeric dopamine dimers from the two-spotted cricket Gryllus bimaculatus.
BIOORGANIC CHEMISTRY.
95,
-
